Integrins in Health and Disease

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Integrins and health.

The cells of the body stick to one another and to the packing material, or extracellular matrix, around them. As might be expected, this adhesion holds tissues together and is therefore essential to survival. Less obviously, it helps to direct both embryonic development and an array of processes in the fully formed organism, including blood clotting, wound healing and eradication of infection. ...

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Leukocyte Beta2-Integrins; Genes and Disease

Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix interactions. Beta2-integrins are expressed exclusively in leukocytes and mediate many important functions in the immune system. Beta2-integrin genes are important in the pathologies of several diseases and genetic syndromes. These include Leukocyte Adhesion Deficiency (LAD) and Systemic Lup...

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The role of Tachykinins in health and disease

Background & Aim: Tachykinin peptide family is one of the largest peptide families in animals that has been first discovered in the gastrointestinal tract about 70 years ago and isolated for the first time from the small intestine and brain. Up to now, more than 40 tachykinins have been extracted from invertebrates (insects, worms and fungi) and vertebrates (skin, gastro-intestinal duct, centra...

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Integrins and proximal signaling mechanisms in cardiovascular disease.

Integrins are heterodimeric cell-surface molecules, which act as the principle mediators of molecular dialog between a cell and its extracellular matrix environment. In addition to their structural functions, integrins mediate signaling from the extracellular space into the cell through integrin-associated signaling and adaptor molecules such as FAK (focal adhesion kinase), ILK (integrin-linked...

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ژورنال

عنوان ژورنال: Biology of extracellular matrix

سال: 2023

ISSN: ['0887-3224', '2191-1959']

DOI: https://doi.org/10.1007/978-3-031-23781-2